Ways to Reduce Your Risk of Relapse How to Reduce Relapse Risk There’s no guaranteed way to prevent depression relapse, but there are steps you can take to reduce your risk. Above all, be mindful that depression — for many people — is a chronic illness, and that relapse is common, Sapra says.e60dc2a1-f33c-4a05-9b50-8e3e8e5976294c51515c-3572-4ee4-8528-9b17266dd7ca “Treatment can help reduce the amount of time you have depression and the proba…