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49ers injury report: George Kittle, Nick Bosa, and Christian McCaffrey cleared to play vs. Rams

San Francisco will have its top playmakers available as the 49ers open the season against the Rams in the NFL’s first regular-season game in Australia.

  • On Thursday, the San Francisco 49ers open their 2026 season against the Los Angeles Rams at the Melbourne Cricket Ground in Australia, with stars Nick Bosa, George Kittle, and Christian McCaffrey expected to play.
  • Both Bosa and Kittle return from significant injuries sustained in 2025, with Bosa recovering from an ACL tear and Kittle from an Achilles injury; head coach Kyle Shanahan plans to manage their workloads carefully.
  • Defensive tackle Alfred Collins is ruled out after sustaining a torn patellar tendon this week, while defensive tackle James Thompson Jr. remains questionable with a hamstring injury.
  • Following Thursday's practice, Bosa said he is "100 percent ready to go for the first game," as the team navigates defensive end Sam Okuayinonu's placement on Injured Reserve last week.
  • Facing the Rams and MVP quarterback Matthew Stafford, San Francisco relies on McCaffrey, who rushed for 1,202 yards and 10 touchdowns during the 2025 season.
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NBC Sports broke the news in Stamford, United States on Wednesday, September 9, 2026.
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