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Experts Reveal Cardinals vs. 49ers Best Bets with Brock Purdy Sidelined, Mac Jones Starting

The 49ers start Mac Jones in Week 3 after Brock Purdy's turf toe injury sidelines him, with Jones having thrown 279 yards and three touchdowns in the previous game.

Summary by Syracuse NY
The San Francisco 49ers enter Sunday’s divisional matchup against the Arizona Cardinals with quarterback uncertainty dominating the headlines. Brock Purdy, who has been battling shoulder and toe injuries, is officially questionable, but head coach Kyle Shanahan has already indicated it’s “highly unlikely” the starter will take the field. Instead, Mac Jones—who led the Niners to victory in Week 2—will be under center at Levi’s Stadium, with Purdy…

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Newsweek broke the news in United States on Friday, September 19, 2025.
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