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Ifinatamab Deruxtecan May Benefit Patients with Recurrent or Progressive ES-SCLC

Ifinatamab deruxtecan showed a 48.2% objective response rate with a disease control rate of 87.6% in heavily pretreated extensive-stage small cell lung cancer patients, supporting further phase 3 trials.

Summary by News Medical
Patients diagnosed with recurrent or progressive extensive-stage small cell lung cancer (ES-SCLC) may benefit from treatment with ifinatamab deruxtecan (I-DXd), a B7-H3–directed antibody–drug conjugate, according to data presented today at the International Association for the Study of Lung Cancer (IASLC) 2025 World Conference on Lung Cancer (WCLC) in Barcelona, Spain.

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Medical Xpress broke the news in on Sunday, September 7, 2025.
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