2026 NFL Week 1 early odds: Cowboys road favorites against Giants

NFL odds: Giants enter NFL Week 1 as home underdogs to rival Cowboys

Find the updated point spread for the Week 1 Sunday Night Football game between the Giants and Cowboys.

NFL picks, predictions against the spread Week 1: Seahawks flex on Patriots, Rams stop 49ers, Giants stun Cowboys

In Sporting News' first picks and predictions against the spread for the 2026 NFL regular season, the Seahawks and Rams get off to great starts as co-favorites in the NFC West, while the Giants and Eagles win in their opening NFC East matchups.

2026 NFL Week 1 early odds: Cowboys road favorites against Giants

Here's a look at the lines for Week 1 in the NFL as we open up the 2026 season.

NFL Week 1 Picks Against the Spread

The NFL season is here. Picking NFL games straight up is hard enough, but picking against the spread is even tougher. Here are NFL week 1 picks against the spread. (Spreads are from Tallysight as of Tuesday morning) Last season: 140-143-2 Wednesday Night New England Patriots at Seattle Seahawks (-3.5) The Seahawks won this matchup in the Super Bowl and didn’t lose a lot from their roster. Their defense can still create problems for the Patriots,…